Monday, January 27, 2020

Detection and Classification of Leukaemia Cells

Detection and Classification of Leukaemia Cells Leukemia is one of the many types of cancers. Leukemia is caused in the white blood cells near the bone marrow region of our body. In this the WBCs which get infected turns blue. Like any other cancer in this also the cell divides itself at the faster pace. Most human cancers are characterized by the aberrant expression of normal and/or mutated genes, and natural selection acts on cancer cells to cause a loss of growth control, angiogenesis, invasion, and metastasis. Even when it is not required they multiply causing a tumor. Detected and treated at an early stage of leukemia saves a lot of lives. The aim of this research is to automate the detection of leukemia cells. In the scientific language, the leukemia cells are known as the blast cells. There are two types of acute leukemia, Acute Lymphoblastic Leukemia (ALL) and Acute Myeloid Leukemia (AML). This thesis focuses on Acute Lymphoblastic Leukemia (ALL). Generally, the process of detection and classification is done manually taki ng up to five days. The motivation behind this research is to improve the diagnostic process by automating it and reducing its time span to five days to few hours. Nowadays, medical imaging is one of the fastest growing fields in medicine, clinical settings and research and development (RD). Image processing in medical field is becoming a subject of prime focus due to its tremendous potential for the public health sector and the scientific community in general. In particular, imaging applications are emerging as a new opportunity as an innovation at the meeting point between medicine and the computer science. Many software and research groups focus on the development of image processing applications for medical images, for example to improve low resolution photographic images and produce effective high quality images. There is no terrifying disease than cancer nowadays. It is often seen as untreatable, un curable and a very painful disease. Leukemia detection helps in detecting blood cancer using two basic modules of image processing i.e. Image segmentation and feature extraction. After these two modules, we use two techniques of neural network i.e. feed forward network and RBFNN for the detection purposes. We compare the accuracy percentage in both of them. The technique with best accuracy percentage is recorded as the more efficient technique. More than 310,000 Americans are living with leukemia. Every day 143 Americansare detectedwith leukemia and 66 lose the fight. [23] A brief overview of leukemia and a conceptual analysis of the main methods used for the detection and classification of leukemia cells facilitating Artificial Intelligence, Cellular Automata and Neural Networks are discussed below. Cancer has become a data-intensive range of investigation, with growing amount of changes in data collection technologies and methodologies. In 1895, Wilhelm Roentgen discovered that X-ray tubes, utilized widely for imaging bones and then for giving a variety of circumstances. The technicians who ran the radiograph machines and many exposed patients were found with skin tumors and leukemia. Accurate diagnosis and sorting of blast cells is an tremendously valuable necessity for the detailed diagnosis of leukemia and has a optimistic impact on treatment and prognosis. BLOOD Blood is important part of human life. An average human body is around 70 liters of liquid from which five liters is blood. Biologically, blood is vital for preserving homeostasis that is keeping the body’s position stable. This discusses to hydration, temperature regulation and ion concentration. a) Transfer of nutrients from the digestive system to wholly parts of the body. b) Transportation of oxygen from the lungs to all parts of a body. c) Transportation of carbon dioxide from all parts of the body to the lungs. d) Transportation of waste products from cells to the external environment, especially via the kidneys. e) Keeping an ongoing discussion of it is mechanisms with tissue fluids and keeping electrolyte balance. f) Defending the body against attack from foreign viruses through the white blood cells and antibodies. g) Shielding the body against injury or illness using the provocative response. h) Preventing serious hemorrhage by the clotting process. Blood has four main fundamentals to ensure it fulfills its functions, shown in Table 1.1 Table 1.1 (a): Major elements of Blood (Red blood cells, White blood cells, Platelets). Table 1.1(b): Major elements of Blood (Plasma). 1.1.2 WHITE BLOOD CELLS A white blood cell is superior to a red blood cell. White blood cell arrangement and concentration in the blood gives appreciated information and plays a crucial role in the diagnosis of different diseases. White blood cells fall into five categories: Neutrophil, Eosinophil, Basophil, Monocyte and Lymphocyte, shown in the Table 1.2. These cells afford the greatest defense against infections, and their discrete concentrations can help authorities to distinguish between the presences or not of severe pathologies. Types of blood cells are discussed in the following table Table 1.2 : White Blood Cells (Neutrophil, Eosinophil, Basophil, monocyte, lymphocyte) 1.1.3 TYPES OF LEUKEMIA Leukemia is a sickness of unidentified cause where the bone marrow produces huge numbers of irregular cells white blood cells that stop increasing before maturity. There are four main types of leukemia, namely Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), which is used as a case study in the thesis, Chronic Lymphocytic Leukemia (CLL) and Chronic Myeloid Leukemia (CML). Most commonly, acute leukemia patients are discussed to specialist units for evaluation. Treatment is based on chemotherapy through the veins, lasting four to six months, which also kills normal body cells. Leukemia can be identified by blood tests while a bone marrow test assists to choose on the best choice of treatment. Table 1.3 includes the types of main leukemia. Table 1.3 : Types of Leukemia Table below shows the UK Leukemia case statistics for males and females in 2007, revealing that the survival rate has increased from 2001 to 2006. The diagnosis and the medical treatment have improved significantly as shown in Figure 2.1. Automated detecting can contribute to the early diagnosis of patients and survival rates are expected to increase in the future. Table 1.4: Leukemia cases in UK for 2007 Figure 1.1: Leukemia 10-year relative survival rates 1.1.4 FLOW CHART OF THE PEOPLE ADMITTED IN THE HOSPITAL Figure 1.2 shows the steps that are essential to be taken by a hematologist in order to identify a patient with acute leukemia. Table 1.5 provides a more thorough explanation of the individual steps in Figure 1.2 NO YES NOYES Table 1.5 : Analytical description of each step in Figure 1.2

Sunday, January 19, 2020

Civilizations

Renaissance is a word which means â€Å"rebirth† in French. In Italian, it means â€Å"Rinascimento†. Renaissance is a cultural revolution in Europe, particularly in Italy which occurred during the latter part of the Middle Ages from 14th century to 17th century. It is the period when great developments and progress in arts and science occurred. It is believed that Renaissance flourished because of the so-called â€Å"Black Death†. People shift their ideas from spiritual life to their lives spent here on Earth. Florence gave way to the birth of renaissance. It is where great men of arts like Da Vinci, Michelangelo and even Boticelli spawned. Renaissance introduced concepts of sciences and arts which until today last. Humanism which is a process of learning was used by renaissance scholars. This method study original texts and review it using reasoning as well as empirical evidences. In arts, artists develop very sensible linear perspective. Painters also considered study of lighting, silhouette and anatomy to improve their works. Architects of renaissance combined mathematics with architecture. Classical style flourished. Dome shaped infrastructures, which seemed impossible to do was achieved. Science experienced â€Å"scientific revolution† in which the scientific method, which is based on empirical evidences, was introduced. This gave rise to development in different branches of science. During renaissance, people have changed the way they see God and man. It results to debates which questioned the Christianity. Aztecs and Incas Aztec was a Mesoamerican empire which exists from 14th to 16th century. Aztecs have rich culture and traditions. Aztecs have human sacrifices to their gods, thus, wars continued in order to have human sacrifices. Army men do not kill their enemies; instead they held them as captives which will be their human sacrifices. When there are no wars, warriors participate into gladiatorial battle. In terms of agriculture, Aztecs are famous for their Hanging Garden. They were very much into gardening. In politics, the king of every city is an appointed judge. The magistrates were elected. People who committed huge crimes will be sacrificed while those who committed lesser crimes will become slaves. On the other hand, the Inca Empire employs strict administration of bureaucracy. The emperor marries her sister to maintain the lineage pure. This civilization also believes in human sacrifices. But it is not always the case, because sometimes they sacrifice animals instead of humans. Other royalties hold administrative designations. Military activities are not common, only in times of troubles like wars and rebellions. There are no records of agricultural activities during the Inca Empire (Tankard, 2006). Umayyad and Abbasid Caliphates Abbasids were able to solidify and unify Islamic leadership. On the other hand, Umayyad had the biggest unitary state during their rule.   They are Sunni Muslims. Abbasid were from the youngest uncle of Muhammad in contrast with the Umayyad were descendants of Umayya who is from another clan. Conflict rise between the two because Abbasid caliphate they are the true descendant of Muhammad. The Umayyad military was used mainly for the expansion of their religious territory while the Abbasid army called the Mameluk was established to prevent the collapse of their rule. In terms of politics, the Abbasid caliph rule with coordination from non-Arab Muslims which contributed to the unification of Islam during their rule. Umayyad was believed to shift from a religious institution to a dynastic body. Tropical People The factors which caused social and cultural changes in the lives of tropical people are architecture, religion, gender and learning. Expansion of Islam results to new architectural styles. Style from the Middle East and locality are fused. In learning, Islam made people from Africa use Arabic. Spread of Islam also introduced the study of Islamic Laws and knowledge about science, mathematics including medicine. Social change occurred when discrepancy between the elites and the poor increased. In Africa and India, slavery became common. Slaves are tasked to do tedious works like mining, while women slaves are asked to do household chores, they also served as entertainers. Women in the tropics were trained to do house chores which includes child rearing, cooking and some farm works. Records do not have clear accounts on the implication of Islamic rule to women in the tropics, but it is known that in some places, women did not practice veiling and seclusion. REFERENCES: Renaissance. Retrieved April 29, 2007 . Tankard, Keith. (2006). â€Å"Aztec and Inca Empire†. Retrieved April 29, 2007 from http://www.knowledge4africa.co.za/worldhistory/inca13.htm   

Saturday, January 11, 2020

Quality is Being Perfect

Achieving quality† is said to be a major issue throughout industry, commerce and government bodies. It†s just not passing craze of flavour of the month. Quality is vital for growth, survival and prosperity of every organisation. Nowadays, more and more organisations are placing greater emphasis on quality in order for them to prosper and become successful. In this essay I will be explaining the different concepts of quality, which are established by different institutes and people. I will then compare these concepts and give my view on each of them. In the second part of this essay I will be looking at areas of commonality and difference between ‘quality of product manufacture† and ‘quality in service†. Quality is difficult to define but what is sure is that we all know when it is achieved and when it is not. This assessment of quality is subjective and it can vary from different perceptions of individuals. It is the perception of the individual, by what influences his experience and what he thinks. Overall, the word quality can mean different things to different people. For example, the first car that I bought appeared to me to be of superior quality, even though it was thirteen years old, had many rust patches and the roof was leaking. On the other hand, a company director who drives a Rolls Royce may think that the car is a load of scrap. The second-hand car to me was quite satisfactory where it got me to my required destinations, but the company director may think it is bad advertisement and unreliable. For this reason, quality can be defined as ‘fitness for purpose†. It can be defined as fitness for purpose because the second-hand car was fit for my purpose. The definition ‘fitness for purpose†, was defined by an early American quality guru, Dr Joseph Juran. He always believed that if a product was fit for purpose, then it was a quality product. But from my perspective, this is not always true. This is because the second-hand car that I bought was fit for my purpose (transported me in safety), but it was not conceived to be a quality car by many of the people who I showed it to, except the sycophants who always tried to please me. Many people stated that the car was a ‘reject† due to the fact that it was rusty and the roof was leaking. Now that I have sold it, I would agree with these people, it was not a quality car, but it was fit for purpose. So therefore, this prime example gives you an indication that ‘fitness for purpose† does not always mean quality. The definition begs the question of ‘whose purpose? † Plato†s (philosopher) theory suggests that it was the customer who defined the purpose and the customer who defined quality. But Juran†s definition does not even mention the purpose of the customer. Another problem with the fitness for purpose definition is that the purpose may not always be known. Juran believes that the majority of quality problems are because of poor management, rather than poor employee work. In general, he believes that management controllable defects account for over 80 per cent of total quality management problems. Overall, Juran†s definition is too elementary where there is a need to closely define to what is going to be offered, then quality can become ‘conformance to requirements†. Conformance to requirement is widely used in industry to define quality. â€Å"This definition is often attributed to Philip Crosby, another well-known guru of quality†. (Owen,B 1995). Crosby believed that if a product were conformed to requirement, then there would be no such thing as a quality problem where the company itself has established its products based directly on its customers† needs. The Crosby definition places an emphasis to meet a certain specification that also leads to an emphasis on the reliability of the product or service. Reliability ranks with quality in importance where â€Å"it is the ability of the product or service to continue to meet the customer requirements†. (Oakland, 1995). Crosby also states that when a product is produced or when a service is delivered, it should have ‘zero defects†, where you should ‘get it right first time†. What zero defects means is not that people never make mistakes, but that the company does not start expecting them to make mistakes. But from my point of view and from Juran†s perspective, the zero defects approach cannot always help an organisation to achieve quality. Juran believes that employees should be given long-term training, where it should start at the top of the hierarchy of the organisation. The problem with Crosby†s quality control approaches are that there can be clear dangers that the customers can become less important than the standard of the product because there is too much emphasis on control and getting things right first time. This is because every organisation should be able to make certain mistakes and learn from them the next time around. One advantage of his approach is that he places more emphasis on prevention, rather than inspection, so therefore, there can be increased quality where the costs can decrease and thus increasing profits. The main problem with Crosby†s definition is that it is too simplistic. Producing a product that is conformed to requirement that has had no problems during the manufacturing process does not necessarily mean that it is a quality product. For example, a golf player who completes a round without breaking the rule is not necessarily a good quality player. Also, a driver who drives home without breaking the law is not necessarily a quality driver The fitness for purpose and conformance to requirement definitions seeks to establish a level of performance that is acceptable to customers where their needs are met and where they have no cause to complain. But between these two levels there is a ‘grey† area, where the specification is achieved, but where the customers may feel that they have not gained value. For this reason quality can be concerned with ‘ providing a service that delights our customers†. This definition was originated by the late American quality guru, Dr W. Edwards Deming. â€Å"He was the first American quality expert to teach Japanese managers about quality. â€Å"Deming†s work in Japan has been identified as putting Japan on the road to leadership in international business and industry†. (Internet). Deming argued that the customer should not just be satisfied, but delighted in order to gain repeat custom. He also stated that you should always keep ahead of your customers† expectations that include every aspect of supplier-customer relationship, not just the product or service being provided. From my perspective, Deming†s approach to quality is much more perplexing than Juran and Crosby†s definitions. Both Juran and Crosby were focused too much on the product, but Deming covers all of the aspects of quality. Deming also allocates the measurement of quality through statistical calculations where Juran and Crosby are more concerned with the production process measurements. Another quality guru, Armand V. Feiggenbaum who is the chairman of the International Academy of Quality, stresses that quality does not mean ‘best†, but ‘best for the customer use and selling price†. What Fienbaum†s definition is trying to say is that products should be produced to customer requirements and be sold at a good reasonable price, thus achieving quality. From my perspective, this is a good definition. For example, if I buy a television that contains a lot of features, it†s reliable, unique and it is at a good reasonable price, then it would be a quality product to me. Also many people associate price with quality, people expect better quality when paying more, thus Fienbaum gives a good clear definition of quality. To Fienbaum, quality is a way of managing an organisation. He stresses that quality does not only mean that customer problems have to be fixed faster. Like Juran, he says that leadership is essential to a company†s success. Finally, I am going to talk about a well known Japanese guru, Kaoru Ishikawa who is known as the father of ‘quality circles†. Ishikawa stresses that ‘quality does not only mean the quality of a product, but also of after sales service, quality of management, the company itself and the human being. Ishikawa†s definition is trying to say that all of the aspects of the organisation have to be known to be of good quality standard. For example, Rolls Royce produces quality cars but also the company itself and the management is known to be of good quality. So therefore if all of the aspects of the organisation are good quality, then this can lead to good corporate reputation, thus increasing sales and profits. Overall, Ishikawa†s definition is similar to Deming†s and Fienbaum†s definition, where there is a focal point to look at all of the stages of providing quality. In conclusion, all of the guru†s definitions are different and have all proved to be successful in their own situations. It is also worth remembering that all the gurus are consultants and have different definitions due to the fact that they come from different business backgrounds, so therefore, their approaches to quality differ from each other. Now that I have defined the different concepts of quality, I am now going to explain the difference between ‘quality in product manufacture† and ‘quality in service delivery†. A product is any goods other than land, bridges or buildings and includes a product which is comprised within another product whether by virtue of being a component part or raw material or otherwise†. (Dale and Plunkett, 1994). On the other hand â€Å"A service encounter is any direct interaction between a service provider and customers†. (Dale and Plunkett, 1994). Industries, such as financial services, health care, tourism, government, transport and communications have their business activities focused on services rather than products. Quality customer service is now a focus of every organisation where it is typically achieving a competitive advantage. â€Å"Consumers, be they individuals, households or businesses, are more aware of the alternatives on offer; in relation to both services/products, and to provide organisations and rising standards of service†. (Dale and Plunkett, 1994). Overall, the quality of service delivery has become as important as the quality of product manufacture. However, they have several characteristics that distinguish them from each other when providing quality to customers. One main difference between quality in product manufacture and quality in service delivery is that products are tangible and services are not. So therefore when manufacturing a product, a firm will have to make sure that there are no defects on the product and that the product is conformed to requirement. This is because if there are any defects on the product, then consumers have a right to complain with tangible evidence (the product). On the other hand, services are intangible; there is usually little or no tangible evidence to show once a service has been performed. For example, when a mortgage adviser has given his proposition to a consumer, later the consumer will have little or no evidence of the service delivery to prove how good or bad it was. So consequently, from one perspective, service organisations can afford to make mistakes and not get blamed for them, although it can lead to a bad corporate image and serious damages, such as in health care situations. Overall, quality in a product will be evident but quality in service delivery does not always have to be evident due to the fact that services can be intangible. Another key difference between these two is that poor quality products can be replaced but poor quality services cannot always be replaced. So therefore, as Philip Crosby says, you will have to ‘get it right first time† with ‘zero defects† when delivering a service. Overall, an organisation can afford to make mistakes when achieving quality in a manufactured product. But an organisation cannot afford to make mistakes when delivering a service due to the fact that it is very hard or impossible to rectify a poor quality service. For example, if a nurse in the hospital drops a baby and as a result, the baby has a brain damage, then this mistake in the service will be very impossible to rectify. So therefore, in services, such as health care, there are generally fewer errors than in products due to the serious consequences that a service organisation (hospital) can face if it makes a mistake. As Deming states, organisations will have to delight the consumer through their services in order to achieve quality. So therefore, it is essential for service providers, such as doctors, to get it right first time. One other major difference is that it is more difficult to use quality standards in services than products, in the conventional sense. This is because there is the characteristic of heterogeneity, where variability exists in services as a function of labour inputs and non-standardisation of delivery. (Dale and Plunkett, 1994). There can be small variations in products but services can have large variations, it all depends on the individual who is delivering the service. Overall, different individuals deliver services in various different ways. Elimination of the virus of variability in products is easier to tackle than services. Deming†s concept of statistical control is widely used in industry in order to eliminate variation in products. The behaviour of the process remains the same over time with controlled variation and by the use of statistical control. If no statistical control is used, then the behaviour of the process is likely to change, usually in unpredictable ways and at unpredictable times with uncontrolled variation. So therefore, statistical control over the manufacturing of products can achieve quality and eliminate variation. But the problem with the statistical concept is that it cannot eliminate variation in service delivery, the statistical concept is only suitable for manufacturing products. From my perspective, training the staff can only eliminate service variation as Juran says. Overall, I think that huge variations in products such as Walkers Crisps can devalue the product because consumers expect the same taste from each packet, that is said to be of good quality and number one in the UK market. However, there is slight variation in Walkers Crisps, but this is usually common with ever packet of crisp. Recently, there was a research taking place in the UK that is working towards eliminating the variation of tastes of each crisp. The elimination of variation in crisps is another step towards achieving quality in product manufacture. On the other hand, it is sometimes said that the variation in services often produce quality. However, variations in services are usually dealt with by training the staff. Last of all, I think that it is harder to achieve and control quality in service delivery than product manufacture. This is because services (such as doctors† time) cannot be stored to meet fluctuations in demand, but products can be stored. In order to conform to requirement and delight the customer (achieve quality), service organisations will have to meet demands at perplexing times, or otherwise they will find it very difficult to achieve quality. An organisation that does not meet fluctuating demands can gain a bad corporate image, thus decreasing the overall quality of the organisation. I think that service organisations can only meet fluctuating demands by setting out standards. For example, opening seven days a week rather than five days a week or specially opening when demands are excessively high. Realistically, this can be very difficult to achieve. A recent example of a service organisation that is not meeting fluctuating demands is the National Health Authority (NHS). The flu syndrome has recently affected many people in the UK, including the elderly. As a result, more people have been attending to the doctors and hospitals, thus making it more difficult for the NHS to cope with the increasing demand levels. Many appointments and operations have been cancelled in many hospitals due to the increase of patients. This prime example gives you an idea that service organisations cannot always deliver quality due to the fact that they cannot always deliver there services on time. In the above example, many people have criticised the NHS of not providing quality services, in other words, not coping with the fluctuation of demand levels. Overall, I think that only if the whole organisational chain is functioning efficiently can quality be achieved in both products and services. The quality chain links all of the business, and its external suppliers, to provide quality to the consumers. This objective is only achieved if each chain link provides quality. If one fails, then the overall objective of achieving quality is very unlikely to be achieved, the chain will not be functioning properly. For example, if a sales assistant does not have enough knowledge on a certain product, then the customer will not receive sufficient information on the product by the sales assistant,thus the quality of the product will be unrecognised. So therefore, the sales assistant is letting every one else down in the quality chain, thus, the chain will not will moving effectively. In overall conclusion, I think that different individuals perceive quality in different ways because everyone has different perceptions. I also think that in their definitions of quality, the gurus are looking at different aspects of quality in order to find different ways of saying the same thing. Basically, ‘meeting customer requirements† achieves quality because you are producing and delivering what the customer wants you to produce and deliver. As well as meeting customer requirements, ‘delighting the customer† is also a good concept of quality because you are going beyond your customers† expectations when delighting your customer with a product or service. However, all the gurus have different definitions due to the fact that they specialise in different business backgrounds, thus they all give a good definition of quality based on their past experiences. There are many differences in achieving quality in a product than achieving quality in a service. One of the differences is that services are tangible and products are not. Thus leaving little or no evidence of service delivery, even though is was not perceived as good quality. However, if mistakes are made in certain services, then these can not always be rectified, but when manufacturing a product, mistakes can usually be rectified easily without facing serious consequences. The main difference between quality in product manufacture and quality in service delivery is that products can be stored to meet fluctuations in demand, but on the other hand, services cannot always be stored, thus decreasing the quality of service delivery. A good example of a service not being stored is the NHS that is not meeting its recent demand levels. Also, another difference between these two is that there is more variation in services than products. Product variations can usually be controlled, but service variations are more difficult to control, thus this can decrease or increase the quality of service delivery. Last of all, I think that it is more important for service providers to ‘get it right first time† due to the fact that poor services are hard to replace, where faulty products are easily replaced.

Thursday, January 2, 2020

Immigration And The United States Essay - 1678 Words

Immigration has been a major uprising debate in the United States ever since immigrants immigrated from European countries in the late 1400s. It all started when Christopher Columbus discovered America in 1492 by accident and took everything away from the Native Americans. Today more than one million people are coming into the United States from many different counties and for many different reasons. The main reason they are coming to the United States is for a better life, they come here chasing, â€Å"The American Dream† trying to escape the chaos of their countries such as crime, violence, and poverty. The United States is known for its opportunities therefor attracting millions of people to immigrate seeking a better future for themselves and their families. This country consists of millions of immigrants from all over the world which makes the Untied States a very diverse country and to some people diversity has a price and it comes with consequences. Critics argue that i mmigrants only have a negative impact upon this country. They claim immigrants are only taking away jobs and bringing crime from other foreign countries. Those who argue against immigration do not realize the importance of immigrants. Immigration is extremely beneficial to this country in multiple ways. Despite the negative impact argued, immigration has impacted the United States positively, mainly economically through its inexpensive labor, making the immigrant work force do all the hard work for aShow MoreRelatedImmigration And The United States986 Words   |  4 PagesImmigration in the United States continues to increase rapidly year by year. According to an analysis of monthly Census Bureau data by the Center for Immigration Studies, the immigration population in the United States, both legal and illegal, hit a record of 42.1 million in the second quarter of this year, an increase of 1.7 million since the same quarter of 2014 (CIS.org). Clearly, Immigrants make up a large par t of the population in the United States, and for most immigrants, migrating to theRead MoreImmigration Of The United States1399 Words   |  6 Pages Michelle Faed English 126 Immigration in the United States The United States of America, being a country established by immigrants, is known all over the world as the land of great opportunities. People from all walks of life travelled across the globe, taking a chance to find a better life for them and their family. Over the years, the population of immigrants has grown immensely, resulting in the currently controversial issue of illegal immigration. 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